John R. Froines, Ph.D.
jfroines@ucla.edu
Professor Froines joined the faculty of the School of Public Health in 1981. He received a B.S. in chemistry from UC Berkeley (1963), M.S. in chemistry (1964) and Ph.D. in physical-organic chemistry (1967) from Yale University. He conducted postdoctoral research at the Royal Institution of Great Britain under Nobel Laureate, Sir George Porter from 1966-68. Before coming to the UCLA School of Public Health, Dr. Froines was Assistant Professor of Chemistry at the University of Oregon and later served as Director of Toxic Substances at the Occupational Safety and Health Administration and Deputy Director of the National Institute for Occupational Safety and Health. Dr. Froines is currently the Director of the Center for Occupational and Environmental Health. He is also the Director of the Southern California Particle Center and Supersite. He is Associate Director of the Southern California Environmental Health Sciences Center and the Director of the UCLA Fogarty Program in Occupational and Environmental Health. Dr. Froines' area of expertise is toxicology and exposure assessment. His research interests are in the qualitative and quantitative characterization of risk factors in environmental and occupational health.
Dr. Froines' research focuses on 1) Chemical mechanisms and exposure assessment related to the health effects from exposure to airborne particulate matter; 2) Evaluation of toxicokinetic factors in defining and characterizing chemical toxicity; and 3) Risk assessment including pollution prevention. His current research emphasizes the study of etiologic factors in air pollution related health effects, but also includes projects to:
1. Study the role of toxicokinetics, and host factors in the carcinogenicity of arsenic and chromium VI.
2. Develop new approaches to exposure assessment for multi-component systems with a focus on measures of internal dose as characterized by evaluation of metabolites, biomarkers and other toxicological factors. In particular, he leads a research project to investigate pesticide exposure among pesticide applicators, farmworkers, and their families in Mexico.
3. Toxicokinetic modeling to explain toxic interactions between multiple chemicals including studies of enhancement and antagonism. He is currently PI on a project to investigate new approaches to addressing exposure to beryllium metal.
Dr. Froines chairs the State of California's Scientific Review Panel; the central review panel at the State level for identifying toxic air contaminants. He is a member of the National Toxicology Program's Board of Scientific Counselors. He is a member of the Institute of Medicine's Environmental Health Roundtable.
Publications:
Morgenstern H, Froines J, Ritz B, and Young B. Epidemiologic Study to Determine Possible Adverse Effect to Rocketdyne/Atomics International Workers from Exposure to Selected Chemicals. Report to the Public Health Institute, 1999.
Ritz B, Morgenstern H, Young BB, Froines J. Effects of Exposure to External Ionizing Radiation on Cancer Mortality in Nuclear Workers Monitored for Radiation at Rocketdyne/Atomics International. American Journal of Industrial Medicine, 35:21-31, 1999.
Froines JR, Barile R. Approaches to Addressing Occupational and Environmental Health Needs in Mexico. International Journal of Occupational Environmental Health, 5:208-212, 1999.
Ritz B, Morgenstern H, Froines J, Moncau J. Chemical Exposures of Rocket-Engine-Test-Stand Personnel and Cancer Mortality in a Cohort of Aerospace Workers. J Occup Environ Med, 41(10):903-910, 1999.
Okoji RS, Leininger J, Froines JR. Subchronic Toxicity Study of Sodium Arsenite in Methyl-Deficient Male C57BL/6 Mice. Arsenic Exposure and Health Effects, Proceedings of the 3rd International Conference on Arsenic Exposure and Health Effects, W. Chappell, C.O. Abernathy, and R.L. Calderon, editors, Elsevier Science, pg. 225-232, 1999.
Froines JR, Sabty R, Farrar C, Fernandez C, Meck N, Tan S, Ashley B. Occupational and Consumer Exposure to Hexavalent Chromium and Analysis of Occupational Exposure to Proposition 65 Chemicals. Final Report to the Public Health Trust, 1999.
Kim SY, Que Hee SS, Froines JR. Optimized Portable Cordless Vacuum Method for Sampling Dry, Hard Surfaces for Dusts. Applied Occupational and Environmental Hygiene, 15(6): 503-511, 2000.
Yu RC, Hsu K-H, Chen C-J, Froines JR. Arsenic Methylation Capacity and Skin Cancer. Cancer Epidemiology, Biomarkers and Prevention, 9:1259-1262, 2000.
The American Lung Association. Urban Air Pollution and Health Inequities: A Workshop Report, Proceedings of the Urban Air Pollution and Health Inequities Workshop, 1999. JR Froines - contributing member. Environmental Health Perspectives, 109 (Suppl 3):357-374, 2001.
Recio R, Robbins WA, Ocampo-Gomez G, Borja-Aburto V, Moran-Martinez J, Froines JR, Garcia Hernandez, RM, Cebrian ME. Organophosphorous Pesticide Exposure Increases the Frequency of Sperm Sex Null Aneuploidy. Environmental Health Perspectives, 109:1237-1240, 2001.
Kim S, Jaques PA, Chang M, Froines JR, Sioutas C. Versatile Aerosol Concentration Enrichment System (VACES) for Simultaneous In Vivo and In Vitro Evaluation of Toxic Effects of Ultrafine, Fine and Coarse Ambient Particles. Part I: Development and Laboratory Characterization. Journal of Aerosol Science, 32:1281-1297, 2001.
Froines JR, Cho AK, Hinds WC, Liu W-C, QueHee SS, Ritz B, Spear RC, Yu RC. Worker Exposure Assessment & Hazard & Medical Surveillance Programs. Final Report to NIOSH, 2001.
Yu RC, Hattis D, Landaw EM, and Froines JR. Toxicokinetic interaction of 2,5-hexanedione and methyl ethyl ketone. Archives of Toxicology, 75:643-652, 2002.
Sabty-Daily R, Luk KK, Froines JR. The Efficiency of Alkaline Extraction for the Recovery of Hexavalent Chromium (CrVI) From Paint Samples and the Stability of CrVI in a Paint. The Analyst 127 (6):852-858, 2002.
Okoji RS, Yu RC, Froines JR. Sodium Arsenite Administration via Drinking Water Increases Genome-wide and Ha-ras DNA Hypomethylation in Methyl-deficient C57BL/6J Mice. Carcinogenesis 23:777-785, 2002.
Li N, Kim S, Wang M, Froines J, Sioutas C, Nel A. Use of a Stratified Oxidative Stress Model to Study the Biological Effects of Ambient Concentrated and Diesel Exhaust Particulate Matter. Inhalation Toxicology 14:459-486, 2002.
Li N, Sioutas C, Cho A, Schmitz D, Misra C, Sempf J, Wang M, Oberley T, Froines J, Nel A. Ultrafine Particulate Pollutants induce Oxidative Stress and Mitochondrial Damage. Environmental Health Perspectives, 111 (4): 455-60, 2003.
Lippmann M, Frampton M, Schwartz J, Dockery D, Schlesinger R, Koutrakis P, Froines J, Nel A, Finkelstein J, Godleski J, Kaufman J, Koenig J, Larson T, Luchtel D, Liu LJS, Oberdorster G, Peters A, Sarnat J, Sioutas C, Suh H, Sullivan J, Utell M, Wichmann E, Zelikoff J. The EPA? Particulate Matter (PM) Health Effects Research Centers Program: A Mid-Course (2 ? year) Report of Status, Progress, and Plans. Environmental Health Perspectives, 111(8): 1074-1092, 2003.
Cho AK, Di Stefano E, You Y, Rodriguez CE, Schmitz DA, Kumagai Y, Miguel AH, Eiguren-Fernandez A, Kobayashi T, Avol E, Froines JR. Determination of Four Quinones in Diesel Exhaust Particles, SRM 1649a and Atmospheric PM2.5. Aerosol Science and Technology, in press 2003.
Yu RC, Teh HW, Jaques PA, Sioutas JR. Quality Control of Semi-Continuous Mobility Size-Fractionated Particle Number Concentration Data. In press, Atmospheric Environment. 2003
Cho, AK, Sioutas, C, Miguel AH, Kumagai Y, Schmitz DA, Misra C, Singh M, Eiguren-Fernandez A, Froines JR. Redox Activity of Airborne Particulate Matter (PM) at different sites in the Los Angeles Basin. Submitted. Atmospheric Environment. 2003
Current Doctoral Students:
Guadelupe Chapa