Hilary Godwin, Ph.D. hgodwin@ucla.edu

Professor Godwin joined the faculty of the School of Public Health in 2006.  She received a B.S. in Chemistry from the University of Chicago in 1989 and a Ph.D. Physical Chemistry from Stanford University in 1994. She conducted postdoctoral research from 1994-1996 at the Johns Hopkins University School of Medicine in the Department of Biophysics and Biophysical Chemistry, where she was a National Institutes of Health postdoctoral fellow.  Prior joining the faculty at UCLA, Dr. Godwin was on the faculty of the Department of Chemistry at Northwestern University, where she was an Assistant Professor (1996-2000), Associate Professor (2000-2006), Associate Chair (2003-2004), and Chair (2004-2006) of Chemistry.  Dr. Godwin has received several awards, including a Camille Dreyfus Teacher-Scholar Award, an Alfred P. Sloan Research Fellowship, a National Science Foundation CAREER Award, a Burroughs Wellcome Fund Toxicology New Investigator Award, and a Camille and Henry Dreyfus New Faculty Award.  She is a Howard Hughes Medical Institute Professor. Dr. Godwin's research focuses on the basic chemical and biological mechanisms by which toxic metal ions affect neurological signaling and development.  Current projects include: (1) determining the effects of lead on gene expression and studying the effects of lead on gene deletion strains in the model organisms S. cerevisiae and P. aeruginosa; (2) studying the biophysical interactions between lead and target proteins; (3) studying the rates and mechanisms of metal exchange in proteins; (4) studying the distribution of toxic metals in urban and rural environments and investigating environmental sources of lead exposure using atomic absorption spectroscopy, ICP-AES, and ICP-MS; (5) developing new methods for detection of lead on surfaces and in cells (in collaboration with Roger Lewis, St. Louis University and Kyle Gee, Molecular Probes/Invitrogen). Current Post-Doc: Elizabeth Suarez, Ph.D Current Doctoral Students (Northwestern University): Dimitar Ivanov Roger (Aeryn) Mayer Ethan Trana

Publications (1999-present):

2006

“Preparation of Media and Buffers with Soluble Lead (Pb2+)” Mayer, R. A.; Godwin, H. A. Anal. Biochem. 2006, 356, 142-144.

“Characterization of the first N2S(alkylthiolate)lead compound:  A model for 3-coordinate lead in biological systems” Andersen, R. J.; diTargani, R. C.; Hancock, R. D.; Stern, C. L.; Goldberg, D. P.; Godwin, H. A. Inorg. Chem. 2006, 45, 16574-6576

2005

"Nanopatterning with Lithography" McFarland, A.D.; Haynes, C.L.; Van Duyne, R.; Godwin, H.A. J. Chem. Ed. 2005, 82, 768A-768B.

"Spectroscopic and Functional Determination of the Interaction of Pb2+ with GATA Proteins" Ghering, A.B.; Jenkins, L.M.M.; Schenck, B.L.; Deo, S.;Mayer, R.A.;Pikaart, M.J.;Omichinski, J.G.; Godwin, H.A. J Am. Chem. Soc. 2005, 127, 3751-3759.

"Reexamination of Lead(II) Coordination Preferences in Sulfur-Rich Sites: Implications for a Critical Mechanism of Lead Poisoning" Magyar, J.S.;Weng, T.C.; Stern, C.M.; Dye, D.F.; Rous, B.W.; Payne, J.C.; Bridgewater, B.M.; Milovilovich, A.; Parkin, G.;Zaleski, J.M.; Penner-Hahn, J.E.; Godwin, H.A. J. Am. Chem. Soc. 2005, 127, 9495-9505.

"Teaching Undergraduates at the Interface of Chemistry and Biology: Challenges and the Opportunities" Godwin, H.A.; Davis, B.L. Nature Chem. Biol. 2005, 1, 176-179. 2004

"Color My Nanoworld", McFarland, Adam D.; Haynes, Christy L.; Mirkin, Chad A.; Van Duyne, Richard P.; Godwin, Hilary A. J. Chem. Educ. 2004, 81, 544A-544B.

"High Metal Concentrations Are Required for Self-Association of Synaptotagmin II” García, R. A. and Godwin, H. A. Biophys. J., 2004, 86, 2455-2466 .

“Spectroscopic Determination of the Thermodynamics of Cobalt and Zinc Binding to GATA Proteins” Ghering, A. B.; Shokes, J. E.; Scott, R. A.; Omichinski, J. G.; Godwin, H. A. Biochemistry, 2004, 43, 8346-835.

2003

“Fundamenal Coordination Chemistry, Environmental Chemistry, and Biochemistry of Lead(II)” Claudio, E. S.; Magyar, J. S.; Godwin, H. A. Prog. Inorg. Chem 2003, 51, 1-144. “Spectropotentiometric Analysis of Metal Binding to Structural Zinc-Binding Sites: Accounting Quantitatively for pH and Metal Ion Buffering Effects” Magyar; J. S.; Godwin, H. A. Analyitical Biochem. 2003, 320, 39-54.

“Spectroscopic Determination of the Binding Affinity of Zinc to the DNA-Binding Domains of Nuclear Hormone Receptors” Payne, J. C;. Rous, B. W.; Tenderholt, A. L; Godwin, H. A. Biochemistry, 2003, 42 14214-14224. 2001

“The Biological Chemistry of Lead” Godwin, H. A. Curr. Opin. Chem. Biol. 2001, 5, 223-227.

“Synaptotagmin I is a Molecular Target for Lead” Bouton, C. M. L. S.; Frelin, L. P.; Forde, C. E.; Godwin, H. A.; Pevsner, J. J. Neurochem. 2001, 76, 1724-1735.

2000

“A Selective, Ratiometric, Fluorescent Sensor for Pb2+” Deo, S.; Godwin, H. A. J. Am. Chem. Soc. 2000, 122, 174-175.

“207Pb-1H Two-Dimensional NMR Spectroscopy: A Useful New Tool for Probing Lead(II) Coordination Chemistry” Claudio, E. S.; ter Horst, M. A.; Forde, C. E.; Stern, C.; Zart, M. K.; Godwin, H. A. Inorg. Chem. 2000, 39, 1391-1397.

"Calcium Triggers An Intramolecular Association Between The C2 Domains of Synaptotagmin" Garcia, R. A.; Forde, C. A.; Godwin, H. A. Proc. Natl. Acad. Sci. U.S.A. 2000, 97, 5883-5888.

"High-Yield Expression and Purification of Recombinant Proteins In Bacteria: A Versatile Vector For Overexpression Of Glutathione S-Transferase Fusion Proteins Containing Two Protease Cleavage Sites" Sehgal, B.; Dunn, R.; Hicke, L.; Godwin, H. A. Anal. Biochem. 2000, 281, 232-234. 1999

“Lead-Fingers: Pb(II)-Binding to Structural Zinc-Binding Domains Determined Directly By Monitoring Lead-Thiolate Charge Transfer Bands” Payne, J. C.; ter Horst, M. A.; Godwin, H. A. J. Am. Chem. Soc. 1999, 121, 6850-6855.