Zuo-Feng Zhang, M.D., Ph.D.
zfzhang@ucla.edu

Professor of Epidemiology

Education:
11/73-11/75 Yangzhou Secondary School of Hygiene
Diploma in Public Health, Yangzhou, China

09/78-08/83 Shanghai Medical University
M.D., Shanghai, China

11/88-07/91 State University of New York at Buffalo
Memorial Roswell Park Cancer Institute
Cancer Epidemiology
Ph.D., Buffalo, New York

Postdoctoral Training:
09/87 - 08/88 Post-Doctoral Research Fellow in Cancer Epidemiology
Division of Descriptive Epidemiology & Division of Biostatistics
International Agency for Research on Cancer (IARC), Lyon, France

Primary Papers:
1. Wu WZ, Zhang ZF. Analysis of potential years of life lost on the mortality data of Suzhou from 1973 to 1983. Chinese Journal of Preventive Medicine 1986; 20(5):272-275.

2. Zhang ZF, Yu SZ. The application of potential years of life lost after eliminating the causes of deaths in epidemiology. Acta Academiae Medicinae Shanghai. 1986; 13(5):351-356.

3. Ding AH, Zhang SI, Sun SF, Li MW, Zhang ZF, Yu SZ. Transformation of cervical dysplasia. Chinese Journal of Obstetrics and Gynecology 1986; 21(2):96-99.

4. Zhang ZF, Yu SZ, Zhou GD. Indoor air pollution of coal fumes as a risk factor of stroke, Shanghai. American Journal Public Health 1988; 78:975-977.

5. Zhang ZF, Yu SZ. The application of relative survival rate in evaluating the effects of cervical cancer screening. Chinese Journal of Hygienic Biostatistics 1988; 5(5):1-4.

6. Zhang ZF, Yu SZ, Li WX, Bernard CK. Smoking, occupational exposure to rubber and lung cancer. British Journal of Industrial Medicine 1989; 46:12-15.

7. Zhang ZF, Parkin DM, Yu SZ, Esteve J, Yang XZ. Risk factors for Cancer of the cervix in a rural population in China. International Journal of Cancer 1989; 43:762-767.

8. Zhang ZF, Parkin DM, Yu SZ, Esteve J, Yang XZ, Day NE. Cervical screening attendance and its effectiveness in a rural population in China. Cancer Detection and Prevention 1989; 13:337-342.

9. Chen YX, Liao CS, Yang XZ, Zhang SJ, Xu JL, Jiao BG, Yu SZ, Zhang ZF. An analysis of epidemic factors in cervical cancer by conditional logistic regression model. Chinese Journal of Medicine 1990; 103(1):55-60.

10. Sarkis AS, Dalbagni G, Cordon-Cardo C, Zhang ZF, Sheinfeld J, Fair WR, Herr HW, Reuter VE. Detection of p53 mutation in T1 bladder carcinomas: A marker for disease progression. Journal of National Cancer Institute 1993; 85(6): 53-59.

11. Zeng ZS & Zhang ZF. Cholecystectomy and colorectal cancer in China. Surgical Oncology 1993; 2: 311-319.

12. Dalbagni G, Presti JC, Reuter VE, Zhang ZF, Sarkis AS, Fair WR, Cordon-Cardo C. Molecular genetic alterations of chromosome 17 and p53 expression in human bladder cancer. Diagnostic Molecular Pathology 1993; 2(1):4-13.

13. Simak R, Madersbacher S, Zhang ZF, and Maier U. The impact of ejaculation on serum prostate specific antigen. Journal of Urology 1993; 150: 895-897.

14. Sarkis AS, Zhang ZF, Cordon-Cardo C, Melamed J, Dalbagni G, Sheinfeld J, Fair WR, Herr HW, Reuter VE. P53 nuclear overexpression in Ta non-invasive papillary transitional cell carcinoma of the bladder. International Journal of Oncology 1993; 3: 355-360

15. Zhang ZF, Sarkis AS, Cordon-Cardo C, Dalbagni G, Aprikian AG, Pollack DM, Melamed J, Sheinfeld J, Fair WR, Herr HW, Reuter VE, Begg C. Tobacco smoking, occupation, and nuclear overexpression of p53 in early stage bladder cancer. Cancer Epidemiology, Biomarkers, & Prevention 1994; 3: 19-24.

16. Lianes P, Orlow I, Zhang ZF, Oliva MR, Reuter VE, Levine AJ, Cordon-Cardo C. Altered patterns of MDM2 and TP53 expression in human bladder cancer. Journal of National Cancer Institute 1994; 86(17): 1325-1330.

17. Schultz P, Herr HW, Zhang ZF, Bajorin DF, Seidman AD, Sarkis AS, Fair WR, Bosl GJ, Scher HI. Neoadjuvant therapy in transitional cell carcinoma of the bladder (TCC): multivariate analysis of prognostic factors for survival in patients treated with methotrexate, vinblastine, adriamycin, and cisplatin (M-VAC) with 5 year follow-up. Journal of Clinical Oncology 1994; 12(7):1394-1401.

18. Begg CB & Zhang ZF. Statistical analysis of molecular epidemiology studies employing case-series. Cancer Epidemiology Biomarkers & Prevention 1994; 3: 173-175.

19. Sarkis AS, Dalbagni G, Cordon-Cardo C, Melamed J, Zhang ZF, Sheinfeld J, Fair WR, Herr HW. Association of p53 nuclear overexpresson and tumor progression in carcinoma in situ of the bladder. Journal of Urology 1994; 152, 388-392.

20. Zhang ZF, Aprikian AG, Sarkis AS, Fair WR, Cordon-Cardo C. Factors associated with p53 nuclear accumulation in prostatic adenocarcinoma. International Journal of Oncology 1994; 4: 897-902.

21. Cordon-Cardo C, Dalbagni G, Saez GT, Oliva MR, Zhang ZF, J Rosai, Reuter VE, Pellicer A. P53 mutations in human bladder cancer: genotypic versus phenotypic patterns. International Journal of Cancer 1994; 56: 347-353.

22. Aprikian AG, Cordon-Cardo C, Fair WR, Zhang ZF, Bazinet M, Hamdy SM, Reuter VE. Neuroendocrine differentiation in metastatic prostatic adenocarcinom. Journal of Urology 1994; 151(4): 914-919.

23. Aprikian AG, Fair WR, Zhang ZF. Survival of prostate cancer patients aged less 50. Cancer 1994; 76(4): 1768-1777.

24. Zhang ZF, Begg C. Is trichomonas vaginalis a cause of cervical neoplasia? Results from a combined analysis of 24 studies. International Journal of Epidemiology 1994; 23(4): 682-690.

25. Zeng ZS, Cohen AM, Guillem JG, Zhang ZF. Evaluation of tissue inhibitor of NM23 as a prognostic markers of human colorectal cancer invasion. British Journal of Cancer 1994; 70, 1025-1030.

26. Aprikian AG, Sarkis AS, Fair WR, Zhang ZF, Fuks Z, Cordon-Cardo C. Immunohistochemical determination of p53 protein nuclear accumulation in prostatic adenocarcinoma. Journal of Urology 1994; 151, 1276-1280.

27. Zeng ZS, Sarkis AS, Zhang ZF, Klimstra DS, Charrytonowicz E, Guillem JG, Cordon-Cardo C, Cohen AM. P53 expression: an independent predictor of survival in lymph node positive colorectal cancer patients. Journal of Clinical Oncology 1994; 12(10): 2043-2050.

28. Zhang ZF, Vena JE, Zielezny M, Graham S, Haughey BP, Brasure J., Marshall JR. Occupational exposure to extreme temperature and risk of testicular cancer. Archives of Environmental Health 1995, 50: 13-18.

29. Zeng ZS, Zhang ZF, Sigardson ER. Toxicity study of hepatic artery infusion chemotherapy with massive dose FUDR in rat. Surgical Oncology 1995, 4: 147-155.

30. Herr HW, Schwalb DM, Zhang ZF, Whitmore WF Jr., Oettgen HF. Intravesical Bacillus Calmette-Guerin (BCG) for superficial bladder cancer: ten year follow-up of a prospective randomized trial. Journal of Clinical Oncology 1995, 13 (6): 1404-1408.

31. Scher HI, Zhang ZF, Cohen L, & Kelly WK. The flutamide withdrawal syndrome: hormone independence re-examined. Advances in Urology 1995, 8: 61-95.

32. Zhang ZF, Zeng ZS, Sarkis AS, Klimstra DS, Charytonowicz E, Guillem JG, Cordon-Cardo C, Cohen AM, Begg C. Family history of cancer, body weight and p53 Nuclear Over-expression in Duke's C Colorectal Cancer. British Journal of Cancer 1995, 71: 888-893.

33. Sarkis A, Bajorin D, Reuter V, Herr H, Netto G, Cordon-Cardo C, Zhang ZF, Schultz P, Scher H. The Prognostic Value of p53 Nuclear Over-expression in Invasive Bladder cancer treated with Neoadjuvant MVAC. Journal Clinical Oncology 1995, 13 (6): 1384-1390.

34. Zhang ZF, Karpeh MS, Lauwers GY, Marrero AM, Pollack D, Cordon-Cardo C, Begg C. A case-series study of p53 nuclear overexpression in early stage stomach cancer. New York Academy of Science 1995, 768: 269-271.

35. Ghossein RA, Scher HI, Gerald WL, Kelly WK, Curley T, Zhang ZF, Rosai J. Detection of circulating tumor cells in patients with localized and metastatic prostatic carcinoma: Clinical implications. Journal Clinical Oncology 1995, 13 (5): 1195-1200.

36. Zhang ZF, Karpeh MS, Lauwers GY, Marrero AM, Pollack D, Cordon-Cardo C, Begg C. Risk Factors and p53 nuclear overexpression in early stage intestinal-type stomach cancer. Cancer Detection and Prevention 1995; 19 (2):156-164.

37. Begg C, Zhang ZF, Sun M, Schantz S, Herr H. Methodology for evaluating incidence of second primary cancers with application to smoking-related cancers from SEER. American Journal of Epidemiology 1995; 142: 653-665.

38. Zeng ZS, Cohen AM, Zhang ZF, Stetler-Stevenson, Guillem JG. Elevated tissue inhibitor metalloproteinase-1 (TIMP-1) RNA in colorectal cancer stroma correlates with lymph node and distant metastases. Clinical Cancer Research 1995, 1: 899-906.

39. Zhang ZF, Graham,S, Yu SZ, Marshall JR, Zielezny M, Chen YX, Sun M, Tang SL, Liao CS, Xu JL, Yang XZ. Trichomonas vaginalis and cervical cancer, a prospective study in China. Annals of Epidemiology, 1995, 5: 325-332.

40. Orlow I, Lacombe L, Hannon GJ, Serrano M, Dalbagni G, Pellicer I, Reuter VE, Zhang ZF, Beach D, Cordon-Cardo C. Deletion of p16 (INK4A/MTS1) and p15 (INK4B/MTS2) in human bladder tumors. Journal of National Cancer Institute 1995, 87: 1524-1529.

41. Pollack D, Jubas J, Zhang ZF, Stellman SD, Harlap S. Reliability of smoking history in medical charts in relation to interview data. International Journal of Oncology 1995, 7: 1379-1382.

42. Scher HI, Zhang ZF, Nanus D, Kelly WK. Hormone and antihormone withdrawal: implications for the management of androgen-independent prostate cancer. Urology 1996, 47: 61-69.

43. Freedman AN, Michalek AM, Marshall JR, Mettlin CJ, Petrelli N, Black J, Zhang ZF, Satchidanand SKS, Asirwatham JE. Familial and Nutritional Risk Factors for p53 Overexpression in Colorectal Cancer. Cancer Epidemiology, Biomarkers and Prevention 1996, 5: 285-291.

44. Theodorescu D, Morash C, Zhang ZF, Fair WR, Russo P. Outcomes of initial surveillance of node negative invasive squamous cell carcinoma of the penis. The Journal of Urology 1996, 155: 1626-1631.

45. Zhang ZF, Zhang ZZ, Yu SZ, Marshall JR, Zielezny M, Graham S, Chen YX, Yang XZ. Geographical distribution of risk factors and incidence of cervical cancer in Southeast China. Journal of Epidemiology & Community Health. 1996, 50: 104-105.

46. Cloos J, Spitz MR, Schantz SP, Hsu TC, Zhang ZF, Hilde T, Braakhuis BJM, Snow GB. Genetic susceptibility to upper aerodigestive tract cancers. Journal of National Cancer Institute. 1996, 88: 530-535

47. Rigas JR, Miller VA, Zhang ZF, Klimstra DS, Tong WP, Kris MG, Warrell RP Jr. Metabolic phenotypes retinoic acid and the risk of lung cancer. Cancer Research 1996, 56: 2692-2696.

48. Freedman AN, Michalek AM, Marshall JR, Mettlin CJ, Petrelli N, Black J, Zhang ZF, Satchidanand SKS, Asirwatham JE. The Relationship Between Smoking History and p53 Overexpression in Colorectal Cancer. British Journal of Cancer 1996, 73: 902-908.

49. Lacombe L, Orlow I, Reuter VE, Fair WR, Dalbagni G, Zhang ZF, Cordon-Cardo C. Microsatellite instability and deletion analysis of chromosome 10q in human prostate cancer International Journal of Cancer 1996, 69(2): 110-113.

50. Li MM, Zhang ZF, Reuter VE, Cordon-Cardo C. Chromosome 3p deletion and microsatellite instability in human bladder carcinoma. American Journal of Pathology 1996, 149 (1): 229-235.

51. Zhang ZF. Epidemiology of Trichomonas Vaginalis. Sexually Transmitted Diseases. 1996, 23 (5): 415-424.

52. Lacombe L, Dalbagni G, Zhang ZF, Fair WR, Cordon-Cardo C, Herr HW, Reuter VE. Overexpression of the p53 protein in a high-risk population of superficial bladder cancer before and after BCG therapy and correlation to the clinical outcome. Journal of Clinical Oncology 1996 14 (10): 2646-2652.

53. Zhang ZF, Kurtz RC, Sun M, Karpeh M, Yu GP, Gargon N, Fein JS, Georgopoulos SK, Harlap S. Adenocarcinomas of the esophagus and gastric cardia: medical conditions, tobacco, alcohol, and socioeconomic factors. Cancer Epidemiology, Biomarkers, & Prevention 1996; 5(10): 761-768.

54. Hardy DO, Scher H, Bodenreider T, Amsterdam A, Zhang ZF, Nanus D, Catterall JF. Androgen receptor CAG repeat lengths in prostate cancer patients - correlation with age at onset. Journal of Clinical Endocrinology & Metabolism 1996; 81 (12): 4400-4405.

55. Simak R, Wiener H, Foeger A, Susani M, Zhang ZF, Marberger M. Cytophotometry of bladder washings in the monitoring of transitional cell cancer under intravesical chemotherapy. European Urology 1996; 29 (4): 391-398.

56. Zheng WX, Sung CJ, Cao PC, Zhang ZF, Cai R, Godwin TA, Kramer EE, Lauchlan SC. Early occurrence and prognosis of p53 alteration in primary cancer of fallopian tube. Gyn. Oncology 1997; 64: 38-48.

57. Zhang ZF, Kurtz RC, Yu GP, Sun M, Karpeh M, Harlap S. Adenocarcinomas of the esophagus and gastric cardia: the role of diet. Nutrition and Cancer 1997; 27: 298-309.

58. Cordon-Cardo C., Zhang Z.F., Dalbagni G, Drobnjak M, Charytonowicz E, Hu SX, Xu HJ, Sheinfeld J, Heer H, Reuter V.E., Benedict WF. Cooperative effects of p53 and pRB alterations in primary superficial bladder tumors. Cancer Research 1997; 57: 1217-1221.

59. Osman I, Scher H, Zhang ZF, Pellicer I, Hamza R, Eissa S, Khaled H, Cordon-Cardo C. Alterations affecting the p53-control pathway in bilharzial-related bladder cancer. Clinical Cancer Research 1997; 3: 531-536.

60. Zhang Z.F., Shu X.M., Cordon-Cardo C., Reuter V.E., Orlow I., Lianes P., Lacombe L., Sarkis A., Scher H, Begg C.B. Smoking and Chromosome 9 alterations in bladder cancer. Cancer Epidemiology, Biomarker, and Prevention 1997; 6: 321-326.

61. Schantz SP, Zhang ZF, Spitz MS, Ming Sun, Hsu TC. Genetic susceptibility to head and neck cancer: the interaction between nutrition and mutagen sensitivity. Laryngoscope 1997; 107: 765-781.

62. Cookson MS, Herr HW, Zhang ZF. Soloway S. Sogani PC. Fair WR. The treated natural history of high risk superficial bladder cancer - 15-year outcome. Journal of Urology. 1997; 158(1):62-67.

63. Osman I, Scher H, Dalbagni G, Reuter V, Zhang ZF, Cordon-Cardo C. Chromosome 16 in primary prostate cancer, a microsatellite analysis. International Journal of Cancer. 1997; 71(4):580-584.

64. Muscad J. Stellman SD, Zhang ZF, Neugut AI, Wynder EL. Cigarette smoking and large cell carcinoma of the lung. Cancer Epidemiology Biomarker & Prevention 1997, 6: 477-480.

65. Ghossein RA, Rosai J, Scher HI, Seiden M, Zhang ZF, Sun M, Chang G, Berlane K, Krithivas K, Kantoff PW. Prognostic signifiance of detection of prostate specific antigen transcripts in the peripheral blood of patients with metastatic hormone refractory prostate carcinoma. Urology 1997; 50(1): 100-105.

66. Zhang ZF, Kurtz RC, Marshall JR. Cigarette smoking and adenocarcinomas of esophagus and gastric cardia [Editorial]. Journal of National Cancer Institute 1997; 89 (17): 1247-1249.

67. Harrison LE, Zhang ZF, Karpeh MS, Kurtz RC. Dietary differences between interestinal and defuse histologic subtypes of gastric adenocarcinoma, a case-control study in the United States. Cancer 1997; 80: 1021-1028.

68. Dalbagni G, Han W, Zhang ZF, Cordon-Cardo C, Saigo P, Fair WR, Herr H, Moore MAS. Evaluation of the telomeric repeat amplification protocol (TRAP) assay as a diagnostic modality in bladder cancer. Clinical Cancer Research 1997; 3: 1593-1598.

69. Yu GP, Ostroff JS, Zhang ZF, Schantz SP. Smoking history and survival of cancer patients: a study based on hospital cancer registry. Cancer Detection and Prevention. 1997; 21 (6): 497-509.

70. Osman I; Scher H; Zhang ZF; Soos TJ; Hamza R; Eissa S; Khaled H; Koff A; Cordon-Cardo C. Expression of cyclin D1, but not cyclins E and A, is related to progression in bilharzial bladder cancer. Clin Cancer Res 1997; 3(12):2247-51

71. Orlow I, Lacombe L, Pellicer I, Rabbani F, Delgado R, Zhang ZF, Szijan I, Cordon-Cardo C. Genotypic and phenotypic characterization of the histoblood group ABO(H) in primary bladder tumors. Int J Cancer 1998;75(6):819-824.

72. Ghossein RA, Coit D, Brennan M, Zhang ZF, Wang Y, Bhattacharya S, Houghton A, Rosai J. Prognostic significance of peripheral blood and bone marrow tyrosinase messenger RNA in malignant melanoma. Clin Cancer Res 1998 Feb;4(2):419-428.

73. Wu RL, Osman I, Wu XR, Lu ML, Zhang ZF, Liang FX, Hamza R, Scher H, Cordon-Cardo C, Sun TT. Uroplakin II gene is expressed in transitional cell carcinoma but not in bilharzial bladder squamous cell carcinoma: alternative pathways of bladder epithelial differentiation and tumor formation. Cancer Res 1998 Mar 15;58(6):1291-1297.

74. Freedman AN; Michalek AM; Weiss HA; Zhang ZF; Marshall JR; Mettlin CJ; Asirwatham JE; Petrelli NJ; Caporaso NE. Aspirin use and p53 expression in colorectal cancer. Cancer Detect Prev 1998;22(3):213-218.

75. Kanetsky PA, Mandelblatt J. Gammon M, Zhang ZF, Ramsey E, Wright TC, et al. Dietary intake and blood levels of folate, vitamin E, retinoids and carotenoids: Association with cervical dysplasia among non-Hispanic, Black women. Nutrition and Cancer 1998; 31(1):31-40

76. Kanetsky PA, Mandelblatt J. Gammon M, Zhang ZF, Ramsey E, Wright TC, et al. Cigarette smoking and cervical dysplasia among immunocompetent, non-hispanic, black women. Cancer Detect Prev 1998;22(2):109-19

77. Cordon-Cardo C, Koff A, Drobnjak M, Capodieci P, Osman I, Gaudin P, Zhang ZF, Massague J, Scher H. Distinct altered patterns of p27kip1 expression in benign prostatic hyperplasia and prostatic carcinoma. Journal of National cancer Institute 1998; 90(17):1284-1291.

78. Zheng W; Khurana R; Farahmand S; Wang Y; Zhang ZF; Felix JC. p53 immunostaining as a significant adjunct diagnostic method for uterine surface carcinoma: precursor of uterine papillary serous carcinoma. Am J Surg Pathol 1998 Dec;22(12):1463-73

79. Dalbagni G, Zhang ZF, Lacombe L, Herr HW. Female urethral carcinoma. A retrospective analysis of the Memorial Sloan-Kettering Cancer Center experience. British Journal of Urology 1998, 82: 835-841

80. Scher H.I., Kelly W. M. K., Zhang Z.-F, Ouyang P., Sun M., Schwartz M., Ding C., Wang W., Horak I.D., Kremer, A.B. Post-therapy Serum Prostate-Specific Antigen Level and Survival in Patients With Androgen-Independent Prostate Cancer. Journal of National Cancer Institute. 1999: 91 (3): 244-251.

81. Kurtz RC, Zhang ZF, Klimstra D, Yu GP, Sun M, Harlap S, JR Marshall. H. Polyri infection and stomach cancer: early or late stage of carcinogenesis. Cancer Detection and Prevention (Accepted)

82. Sabbatini P, Larson S, Kremer A, Zhang ZF, Sun M, Horak I, Conolly M, Ouyang P, Scher H. The prognostic significance of extent of disease in bone in patients with androgen independent prostate cancer. Journal of Clinical Oncology. (In press)

83. Orlow I, Drobnjak M, Zhang ZF, Lewis J, Woodruff J, Murray Brennan M, Cordon-Cardo C. Alterations of the INK4B genes in adult soft tissue sarcomas. Dependence on p53 and RB pathways. JNCI 1999; 91: 73-79.

84. Dalbagni G, Zhang ZF, Lacombe L, Herr HW. Male urethral carcinoma. A retrospective analysis of the Memorial Sloan-Kettering Cancer Center experience. Urology (In press)

85. Zhang ZF, Morgenstern H, Spitz MR, Yu GP, Marshall JM, Tashkin D, Hsu TC, Schantz SP. Marijuana smoking and increased risk of squamous cell carcinoma of the head and neck. Cancer Epidemiology Biomarkers and Prevention (in press)

86. Allen PJ; Zhang ZF; Coit DG. Surgical management of Merkel cell carcinoma. Ann Surg 1999 Jan;229(1):97-105

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