EPIDEMIOLOGY 227 - AIDS: A MAJOR PUBLIC HEALTH CHALLENGE
Spring Quarter 2008, Wednesdays and Fridays, 10:00-noon
Location 71-269 CHS
Instructor - Roger Detels, M.D., M.S.
Teaching Assistant: Julie Hsieh, JJHSIEH@ucla.edu
Office location/hours: Wednesdays from 12-1 pm in Room 21-245 CHS
|
Date |
Topic |
Lecturer |
| Wed, April 2 | The Epidemiology of HIV/AIDS | Roger Detels |
| Slide Presentation (Powerpoint) | ||
| Slide Presentation (PDF) | ||
|
Readings |
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| Fauci AS. The AIDS epidemic. New Engl J Med 341(14):1046-1050, 1999. | ||
| Detels R. The role of epidemiology in challenging the HIV/AIDS pandemic. J Epidemiol 11(2):95-102, 2001. | ||
| Abdool Karim SS, Karim QA, Detels R. Acquired immunodeficiency syndrome. In Oxford Textbook of Public Health: The Practice of Public Health, 5th ed, Detels R, McEwen J, Beaglehole R, Tanaka H (eds). Oxford University Press, Oxford England, 2008 (in press). | ||
| Fri, April 4 | The Natural History of HIV Infection - Molecular, Host, Community | Roger Detels |
| Slide Presentation (Powerpoint) | ||
| Slide Presentation (PDF) | ||
|
Readings |
||
| Barre-Sinoussi F. HIV as the cause of AIDS. Lancet 348:31-35, 1996. | ||
| Feinberg MB. Changing the natural history of HIV disease. Lancet 348:239-246, 1996. | ||
| HIV lifecycle: http://www.hivinfosource.org/animation.html | ||
| Wed, April 9 | The Response of the Immune System to HIV | Beth Jamieson |
| Slide Presentation (Powerpoint) | ||
| Slide Presentation (PDF) | ||
| Glossary of terms | ||
| Hopkin M. Can superantibody drugs be tamed? Nature 440:855-856, 2006 | ||
|
Huston DP. The biology of the immune system. JAMA 278(22):1804-1814, 1997. |
||
| Fri, April 11 | HIV/AIDS in Developing Countries | Roger Detels |
| Slide Presentation (Powerpoint) | ||
| Slide Presentation (PDF) | ||
|
Reading |
||
| Ojikutu BO, Stone VE. Women, inequality, and the burden of HIV. New Engl J Med 352:649-652, 2005. | ||
| Lamptey P, Wilson D. Scaling up AIDS treatment: what is the potential impact and what are the risks? Public Library of Science 2(2):102-104, 2005. | ||
| Beyrer C, Stephens H. Transmission of HIV and other infections in southeast Asia. In AIDS in Asia, Lu Y and Essex M (eds). Kluwer Academic, Plenum Publishers, New York, NY, 2004, pp. 317-333. | ||
| Detels R. HIV/AIDS in Asia: Introduction. AIDS Ed Prev 16A:1-6, 2004 | ||
| Wed, April 16 | The Biology of the Human Immunodeficiency Virus | Jerome Zack |
| Slide Presentation (Powerpoint) | ||
| Slide Presentation (PDF) | ||
|
Reading |
||
|
Douek DC, Picker LJ, Koup RA. T cell dynamics in HIV-1 infection. Annu Rev Immunol 21:265-304,2003. |
||
| Fri, April 18 |
Clinical Manifestations of HIV Infection: Therapeutic Rationale and Treatment of HIV Infection |
Ronald Mitsuyasu |
| Slide Presentation Powerpoint PDF - updated 25 April | ||
| Supplemental information on clinical manifestations and treatment regimens (not presented in class) Powerpoint PDF | ||
|
Reading |
||
| Detels R, Muņoz A, McFarlane G, Kingsley LA, Margolick J, Giorgi J, Schrager LK, Phair JP. Effectiveness of potent antiretroviral therapy on time to AIDS and death in men with known HIV infection duration. JAMA 1998;280(17):1497-1503. | ||
| Wed, April 23 | Pathologic and Neurologic Manifestations of HIV/AIDS | |
| Slide Presentation Powerpoint PDF - updated 25 April | Eric Miller 10-11 | |
| Slide Presentation Powerpoint PDF | Harry Vinters 11-noon | |
|
Readings |
||
|
Anthony IC, Bell JE. The neuropathology of HIV/AIDS. Intl Rev Psychiatr 20(1):15-24, 2008. |
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| Brew BJ, Letendre SL. Biomarkers of HIV related central nervous system disease. Intl Rev Psychiatr 20(1):73-88. | ||
| Power C, Gill MJ, Johnson RT. The neuropathogenesis of HIV infection: host-virus interaction and the impact of therapy. Can J Neurol Sci 29:19-32, 2002. | ||
|
Hinkin CH, Castellon SA, van Gorp WG, Satz P. Neuropsychological features of HIV disease. In Practitioner's Guide to the Neuropsychiatry of HIV/AIDS, van Gorp WG, Buckingham SL (eds). The Guildford Press, New York, NY, 1998, Chapter 1, pp. 1-41. |
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|
Ellison D, Love S, Chimelli L, Harding BN, Lowe J, Vinters HV. Neuropathology: A Reference Text of CNS Pathology, 2nd ed. Mosby, London, England, 2004, pp. 300-318. |
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| (NOTE: If your computer cannot open the link for this, save to your hard disk and open the file through PDF) | ||
| Fri, April 25 | Vertical Transmission of HIV and Pediatric AIDS | Yvonne Bryson |
| Slide Presentation Powerpoint PDF | ||
|
Reading |
||
| Beckerman KP. Long-term findings of HIVNET 012: the next step. Lancet 362:842-843, 2003. | ||
| Wed, April 30 | HIV/AIDS in the Gay Community (10:00-11:00) | Lee Kozinski |
| Slide Presentation Powerpoint PDF | ||
|
Reading |
||
|
Wolitski RJ, Valdiserri RO, Denning PH, Levine WC. Are we headed for a resurgence of the HIV epidemic among men who have sex with men? Am J Public Hlth 91:883-888, 2001. |
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| HIV/AIDS in the African-American Community (10:00-11:00) | Ewok Kwa Sey | |
| Slide Presentation Powerpoint PDF | ||
|
Readings |
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| Bogart LM, Thorburn S. Are HIV/AIDS conspiracy beliefs a barrier to HIV prevention among African Americans? JAIDS 38(2):213-219, 2005. | ||
| Wohl AR, Johnson DF, Lu S, Jordan W, Beall G, Currier J, Simon PA. HIV risk behaviors among African American men in Los Angeles County who self-identify as heterosexual. JAIDS 31:354-360, 2002. | ||
| African Americans and HIV/AIDS. Kaiser Family Foundation Fact Sheet, February 2005. | ||
| Fri, May 2 | HIV/AIDS in the Latino Community (11:00-noon) | Cesar Portillo |
| Slide Presentation Powerpoint PDF | ||
|
Reading |
||
| Latino Congressional Briefing | ||
| MIDTERM EXAMINATION | ||
| 2008 Midterm key | ||
| Midterm results | ||
| Wed, May 7 | Federal and State Policy Towards HIV/AIDS (10:00-11:00) | Arleen Liebowitz |
| Slide Presentation Powerpoint PDF | ||
| Fri, May 9 | Surveillance Strategies | Roger Detels |
| Slide Presentation Powerpoint PDF | ||
|
Reading |
||
| Berkelman RL, Stroup DF, Buehler JW. Public health surveillance. In: Detels R, McEwen J, Beaglehole R, Tanaka H, eds. Oxford Textbook of Public Health: The Methods of Public Health, vol 2, 4th ed. Oxford, England: Oxford University Press, 2002, pp. 759-778. | ||
| Wed, May 14 | Bloodborne Transmission of HIV | Dennis Goldfinger |
| The following is from Dr. Zyman's lecture in 2007, for your reference only - Dr. Goldfinger will be writing on the board instead of giving a Powerpoint presentation | ||
| Dr. Zyman's Slide Presentation 2007 Powerpoint PDF | ||
| Fri, May 16 | Ethics of HIV/AIDS | Roger Detels |
| Slide Presentation Powerpoint PDF | ||
|
Reading |
||
| The Declaration of Helsinki. October 2000. | ||
| Calman KC, Downie RS. Ethical principles and ethical issues in public health. In Oxford Textbook of Public Health: The Practice of Public Health, Detels R, McEwen J, Beaglehole R, Tanaka H (eds). Oxford University Press, Oxford England, 2002, pp. 387-399. | ||
| Wed., May 21 | Behavioral Prevention | Thomas Coates |
| Slide Presentation Powerpoint PDF | ||
| Fri, May 23 | HIV/AIDS and Drug Use in the U.S. (10:00-11:00) | Steven Shoptaw |
| Slide Presentation Powerpoint PDF | ||
|
Reading |
||
| Specter M. Higher risk. The New Yorker, pp 38-45; May 23, 2005. | ||
| HIV/AIDS and Drug Use in Asia (11:00-noon) | Roger Detels | |
| Slide Presentation Powerpoint PDF | ||
|
Readings (Detels) |
||
| Tran NT, Detels R, Nguyen TH, Hoang TL, Pham THN. Drug use, sexual behaviours and practices among male drug users in Hanoi, Vietnam. Int J Drug Policy 15(3):182-188, 2004. | ||
|
Tran NT, Detels R, Long HT, Lan HP. Drug use among female sex workers in Hanoi, Vietnam. Addiction 100:619-625, 2005. |
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| Wed., May 28 | Qualitative Strategies | Eli Lieber |
| Slide Presentation Powerpoint PDF | ||
| Fri, May 30 | Testing Strategies | Ralph Frerichs |
| Slide Presentation PDF Animated version (under "guest lectures": http://www.ph.ucla.edu/epi/faculty/frerichs.html | ||
|
Readings (Frerichs) |
||
| Brown J, Shesser R, Simon G, Bahn M, Czarnogorski M, Kuo I, Magnus M, Sikka N. Routine HIV screening in the emergency department using the new US Centers for Disease Control and Prevention guidelines. JAIDS 46(4):395-401, 2007. | ||
| Wed., June 4 | The Multicenter AIDS Cohort Study (MACS) | Roger Detels |
| John Oishi | ||
| Slide Presentation Powerpoint PDF | ||
| Fri, June 6 | Public Health Intervention | Roger Detels |
| Slide Presentation Powerpoint PDF | ||
| HIV Vaccine Glossary, NIAID, 2002 | ||
|
Readings |
||
| UNAIDS, 2006 | ||
| Kresge KJ. And the winner is... HIV treatment and prevention. IAVI Report 11(1):1-5, 2007 | ||
| PEPFAR and the fight against HIV/AIDS. Lancet 369(9568):1141, 2007 | ||
| Mark Dybul: US Global AIDS coordinator in charge of PEPFAR. Lancet 369(9568):1161, 2007 | ||
|
Ho DD. A shot in the arm for AIDS vaccine research. Public Library of Science 2(2):100-101, 2005. |
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| Coordinating Committee of the Global HIV/AIDS Vaccine Enterprise. The Global HIV/AIDS vaccine enterprise: scientific strategic plan. Public Library of Science 2(2):100-101, 2005. | ||
| Wu Z, Sun X, Sullivan, SG, Detels R. HIV testing in China. Science 312:475-476, 2006. | ||
| Final exam: | ||
| Review session -
Friday, 3-5 pm, CHS 71-257 |
||
| Wednesday, June 11, 2008, 11:30 am- 2:30 pm | ||
| Final key of 2008 | ||
| Final results - with letter grades | ||