EPIDEMIOLOGY 227 - AIDS: A MAJOR PUBLIC HEALTH CHALLENGE
Spring Quarter 2009, Wednesdays and Fridays, 10:00-noon
Location 71-257 CHS
Instructor - Roger Detels, M.D., M.S.
Teaching Assistant: Giridhar Babu
Office location/hours:
Retrovirus meeting in Montreal Canada 2009 - commentary in Science
A new agenda for children affected by HIV/AIDS - Lancet
Proposed state budget cuts that would greatly affect the State Office of AIDS
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Date |
Topic |
Lecturer |
| Wed, April 1 | The Epidemiology of HIV/AIDS | Roger Detels |
| Slide Presentation (Powerpoint) | ||
| Slide Presentation (PDF) | ||
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Readings |
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| Fauci AS. The AIDS epidemic. New Engl J Med 341(14):1046-1050, 1999. | ||
| Detels R. The role of epidemiology in challenging the HIV/AIDS pandemic. J Epidemiol 11(2):95-102, 2001. | ||
| Abdool Karim SS, Karim QA, Detels R. Acquired immunodeficiency syndrome. In Oxford Textbook of Public Health: The Practice of Public Health, 5th ed, Detels R, McEwen J, Beaglehole R, Tanaka H (eds). Oxford University Press, Oxford England, 2009 (in press). | ||
| Fri, April 3 | The Natural History of HIV Infection - Molecular, Host, Community | Roger Detels |
| Slide Presentation (Powerpoint) | ||
| Slide Presentation (PDF) | ||
|
Readings |
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| Barre-Sinoussi F. HIV as the cause of AIDS. Lancet 348:31-35, 1996. | ||
| Feinberg MB. Changing the natural history of HIV disease. Lancet 348:239-246, 1996. | ||
| HIV lifecycle: http://www.hivinfosource.org/animation.html | ||
| Wed, April 8 | HIV/AIDS in Developing Countries | Roger Detels |
| Slide Presentation (Powerpoint) | ||
| Slide Presentation (PDF) | ||
|
Reading |
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| Ojikutu BO, Stone VE. Women, inequality, and the burden of HIV. New Engl J Med 352:649-652, 2005. | ||
| Lamptey P, Wilson D. Scaling up AIDS treatment: what is the potential impact and what are the risks? Public Library of Science 2(2):102-104, 2005. | ||
| Beyrer C, Stephens H. Transmission of HIV and other infections in southeast Asia. In AIDS in Asia, Lu Y and Essex M (eds). Kluwer Academic, Plenum Publishers, New York, NY, 2004, pp. 317-333. | ||
| Detels R. HIV/AIDS in Asia: Introduction. AIDS Ed Prev 16A:1-6, 2004 | ||
| Fri, April 10 | The Response of the Immune System to HIV | Beth Jamieson |
| Slide Presentation (Powerpoint) | ||
| Slide Presentation (PDF) | ||
| Glossary of terms | ||
| Hopkin M. Can superantibody drugs be tamed? Nature 440:855-856, 2006 | ||
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Huston DP. The biology of the immune system. JAMA 278(22):1804-1814, 1997. |
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| Wed, April 15 | The Biology of the Human Immunodeficiency Virus | Jerome Zack |
| Slide Presentation (Powerpoint) | ||
| Slide Presentation (PDF) | ||
|
Reading |
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Douek DC, Picker LJ, Koup RA. T cell dynamics in HIV-1 infection. Annu Rev Immunol 21:265-304,2003. |
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| Fri, April 17 |
Clinical Manifestations of HIV Infection: Therapeutic Rationale and Treatment of HIV Infection |
Ronald Mitsuyasu |
| Slide Presentation Powerpoint PDF | ||
| Supplemental information on clinical manifestations and treatment regimens (not presented in class) Powerpoint PDF | ||
|
Reading |
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| Detels R, Muñoz A, McFarlane G, Kingsley LA, Margolick J, Giorgi J, Schrager LK, Phair JP. Effectiveness of potent antiretroviral therapy on time to AIDS and death in men with known HIV infection duration. JAMA 1998;280(17):1497-1503. | ||
| Wed, April 22 | Pathologic and Neurologic Manifestations of HIV/AIDS | |
| Slide Presentation Powerpoint PDF | Eric Miller 10-11 | |
| Slide Presentation Powerpoint PDF | Harry Vinters 11-noon | |
|
Readings |
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Anthony IC, Bell JE. The neuropathology of HIV/AIDS. Intl Rev Psychiatr 20(1):15-24, 2008. |
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| Brew BJ, Letendre SL. Biomarkers of HIV related central nervous system disease. Intl Rev Psychiatr 20(1):73-88. | ||
| Power C, Gill MJ, Johnson RT. The neuropathogenesis of HIV infection: host-virus interaction and the impact of therapy. Can J Neurol Sci 29:19-32, 2002. | ||
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Hinkin CH, Castellon SA, van Gorp WG, Satz P. Neuropsychological features of HIV disease. In Practitioner's Guide to the Neuropsychiatry of HIV/AIDS, van Gorp WG, Buckingham SL (eds). The Guildford Press, New York, NY, 1998, Chapter 1, pp. 1-41. |
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Ellison D, Love S, Chimelli L, Harding BN, Lowe J, Vinters HV. Neuropathology: A Reference Text of CNS Pathology, 2nd ed. Mosby, London, England, 2004, pp. 300-318. |
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| (NOTE: If your computer cannot open the link for this, save to your hard disk and open the file through PDF) | ||
| Fri, April 24 | Vertical Transmission of HIV and Pediatric AIDS (10-11 am) | Yvonne Bryson |
| Slide Presentation Powerpoint PDF | ||
|
Reading |
||
| Beckerman KP. Long-term findings of HIVNET 012: the next step. Lancet 362:842-843, 2003. | ||
| MIDTERM | ||
| 2009 midterm with answers | ||
| Midterm results | ||
| Midterm scoring frequency graph | ||
| Wed, April 29 | HIV/AIDS in the African-American Community | Nina Harawa |
| Slide Presentation Powerpoint PDF | ||
|
Readings |
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| Bogart LM, Thorburn S. Are HIV/AIDS conspiracy beliefs a barrier to HIV prevention among African Americans? JAIDS 38(2):213-219, 2005. | ||
| Wohl AR, Johnson DF, Lu S, Jordan W, Beall G, Currier J, Simon PA. HIV risk behaviors among African American men in Los Angeles County who self-identify as heterosexual. JAIDS 31:354-360, 2002. | ||
| African Americans and HIV/AIDS. Kaiser Family Foundation Fact Sheet, February 2005. | ||
| Wilson P. Left Behind: Black America: A Neglected Priority in the Global AIDS Epidemic. IAS Newsletter, March 2009 | ||
| HIV/AIDS Amongst Black Americans. International AIDS Society Newsletter, March 2009 | ||
| Fri, May 1 | HIV/AIDS in the Latino Community | Octavio J. Vallejo |
| Slide Presentation Powerpoint PDF | ||
| HIV/AIDS among Latinos in California (PDF) | ||
|
Reading |
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| Latino Congressional Briefing | ||
| HIV/AIDS among Mexican Migrants and Recent Immigrants in California and Mexico | ||
| Wed, May 6 | Federal and State Policy Towards HIV/AIDS (10:00-11:00) | Arleen Leibowitz |
| Slide Presentation Powerpoint PDF | ||
| Reading | ||
| Zuniga JM. IAPAC recommendations to the Obama Administration for the US response to the global HIV pandemic. JIAPAC 1:13-20, 2009. | ||
| Fri., May 8 | Qualitative Strategies | Eli Lieber |
| Slide Presentation Powerpoint PDF | ||
| Lieber et al. Sociocultural contexts and communication about sex in China: informing HIV/STD prevention programs. AIDS Ed Prevent, in press, 2009 | ||
| Wed, May 13 | Bloodborne Transmission of HIV | Ross Heron, American Red Cross |
| Slide Presentation Powerpoint PDF | ||
| Fri, May 15 | Surveillance Strategies | Roger Detels |
| Slide Presentation minor updates made 14 May Powerpoint PDF | ||
|
Reading |
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| Sullivan SG, Wu Z, Detels R. Missed opportunities for testing in Asia. | ||
| Berkelman RL, Stroup DF, Buehler JW. Public health surveillance. In: Detels R, McEwen J, Beaglehole R, Tanaka H, eds. Oxford Textbook of Public Health: The Methods of Public Health, vol 2, 4th ed. Oxford, England: Oxford University Press, 2002, pp. 759-778. | ||
| Revised Surveillance Case Definitions for HIV Infection Among Adults, Adolescents, and Children Aged <18 Months and for HIV Infection and AIDS Among Children Aged 18 Months to <13 Years --- United States, 2008. MMWR 57(RR10);1-8, 2008. | ||
| Wed., May 20 | Behavioural Intervention | Dallas Swendeman |
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Reading |
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Rotheram-Borus MJ, Swendeman D, Flannery D, Rice E, Adamson DM, Ingram B. Common factors in effective HIV prevention programs. AIDS Behav, 2009, in press. |
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| Common principles embedded in effective adolescent HIV prevention programs. AIDS Behav, 2009, in press. | ||
| Common processes in evidence-based adolescent HIV prevention programs. AIDS Behav 12:374–383, 2008. | ||
| Fri, May 22 | HIV/AIDS and Drug Use in the U.S. (10:00-11:00) | Steven Shoptaw |
| Slide Presentation Powerpoint PDF | ||
|
Reading |
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| Specter M. Higher risk. The New Yorker, pp 38-45; May 23, 2005. | ||
| HIV/AIDS and Drug Use in Asia (11:00-noon) | Roger Detels | |
| Slide Presentation Powerpoint PDF | ||
|
Readings (Detels) |
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| Tran NT, Detels R, Nguyen TH, Hoang TL, Pham THN. Drug use, sexual behaviours and practices among male drug users in Hanoi, Vietnam. Int J Drug Policy 15(3):182-188, 2004. | ||
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Tran NT, Detels R, Long HT, Lan HP. Drug use among female sex workers in Hanoi, Vietnam. Addiction 100:619-625, 2005. |
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| Wed, May 27 | HIV/AIDS in the Gay Community (10:00-11:50) | Lee Kozinski |
| Slide Presentation Powerpoint PDF | ||
|
Reading |
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Wolitski RJ, Valdiserri RO, Denning PH, Levine WC. Are we headed for a resurgence of the HIV epidemic among men who have sex with men? Am J Public Hlth 91:883-888, 2001. |
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| Fri, May 29 | Ethics of HIV/AIDS | Roger Detels |
| Slide Presentation Powerpoint PDF | ||
|
Reading |
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| The Declaration of Helsinki. October 2000. | ||
| Calman KC, Downie RS. Ethical principles and ethical issues in public health. In Oxford Textbook of Public Health: The Practice of Public Health, Detels R, McEwen J, Beaglehole R, Tanaka H (eds). Oxford University Press, Oxford England, 2002, pp. 387-399. | ||
| Wed., June 3 | The Multicenter AIDS Cohort Study (MACS) | Roger Detels |
| John Oishi | ||
| Slide Presentation Powerpoint PDF | ||
| Fri, June 5 | Public Health Intervention | Roger Detels |
| Slide Presentation Powerpoint PDF | ||
| HIV Vaccine Glossary, NIAID, 2002 | ||
|
Readings |
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| UNAIDS, 2006 | ||
| Kresge KJ. And the winner is... HIV treatment and prevention. IAVI Report 11(1):1-5, 2007 | ||
| PEPFAR and the fight against HIV/AIDS. Lancet 369(9568):1141, 2007 | ||
| Mark Dybul: US Global AIDS coordinator in charge of PEPFAR. Lancet 369(9568):1161, 2007 | ||
|
Ho DD. A shot in the arm for AIDS vaccine research. Public Library of Science 2(2):100-101, 2005. |
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| Coordinating Committee of the Global HIV/AIDS Vaccine Enterprise. The Global HIV/AIDS vaccine enterprise: scientific strategic plan. Public Library of Science 2(2):100-101, 2005. | ||
| Wu Z, Sun X, Sullivan, SG, Detels R. HIV testing in China. Science 312:475-476, 2006. | ||
| Treating TB, AIDS co-infection: http://www.hindu.com/seta/2009/05/21/stories/2009052150101200.htm | ||
| Reading: Initiation of ART | ||
| Wood R, Lawn SD. Should the CD4 threshold for starting ART be raised? Lancet 373:1314-16, 2009. | ||
| When to Start Consortium. Timing of initiation of ART in AIDS-free HIV-1-infected patients: a collaborative analysis of 18 HIV cohort studies. Lancet 373:1352-63, 2009. | ||
| Tues, June 9 | Final exam: 8:00-11:00 am, 71-257 CHS | |
| 2009 final exam key | ||
| Results | ||
| Grading curve | ||