EPIDEMIOLOGY 227 - AIDS: A MAJOR PUBLIC HEALTH CHALLENGE
Spring Quarter 2011, Wednesdays and Fridays, 10:00-noon
Location 71-257 CHS
Instructor - Roger Detels, M.D., M.S.
Teaching Assistant: Sanchita Ray, raysanchita@yahoo.co.in
Office location/hours: Wednesday noon-1 PM, 73-318 CHS
20 APRIL ONLY - 4:00-5:00, room 71-236 CHS
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Date |
Topic |
Lecturer |
| Wed, March 30 | The Epidemiology of HIV/AIDS | Roger Detels |
| Slide Presentation (Powerpoint) | ||
| Slide Presentation (PDF) | ||
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Readings |
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| Fauci AS. The AIDS epidemic. New Engl J Med 341(14):1046-1050, 1999. | ||
| Detels R. The role of epidemiology in challenging the HIV/AIDS pandemic. J Epidemiol 11(2):95-102, 2001. | ||
| Abdool Karim SS, Karim QA, Detels R. Acquired immunodeficiency syndrome. In Oxford Textbook of Public Health: The Practice of Public Health, 5th ed, Detels R, McEwen J, Beaglehole R, Tanaka H (eds). Oxford University Press, Oxford England, 2009 (in press). | ||
| Fri, April 1 | HIV/AIDS in Developing Countries | Roger Detels |
| Slide Presentation (Powerpoint) | ||
| Slide Presentation (PDF) | ||
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Reading |
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| Ojikutu BO, Stone VE. Women, inequality, and the burden of HIV. New Engl J Med 352:649-652, 2005. | ||
| Lamptey P, Wilson D. Scaling up AIDS treatment: what is the potential impact and what are the risks? Public Library of Science 2(2):102-104, 2005. | ||
| Beyrer C, Stephens H. Transmission of HIV and other infections in southeast Asia. In AIDS in Asia, Lu Y and Essex M (eds). Kluwer Academic, Plenum Publishers, New York, NY, 2004, pp. 317-333. | ||
| Detels R. HIV/AIDS in Asia: Introduction. AIDS Ed Prev 16A:1-6, 2004 | ||
| Wed, April 6 | The Natural History of HIV Infection - Molecular, Host, Community | Roger Detels |
| Slide Presentation (Powerpoint) | ||
| Slide Presentation (PDF) | ||
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Readings |
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| Barre-Sinoussi F. HIV as the cause of AIDS. Lancet 348:31-35, 1996. | ||
| Feinberg MB. Changing the natural history of HIV disease. Lancet 348:239-246, 1996. | ||
| HIV lifecycle: http://www.hivinfosource.org/animation.html | ||
| Cohen J. the ins and outs of HIV. Science 327:1196-1197, 2010. | ||
| Koop CE. The early days of AIDS, as I remember them. Forum for Collaborative HIV Research 13(2):5-10, 2011. | ||
| Fri, April 8 | The Biology of the Human Immunodeficiency Virus | Jerome Zack |
| Slide Presentation (Powerpoint) | ||
| Slide Presentation (PDF) | ||
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Reading |
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Douek DC, Picker LJ, Koup RA. T cell dynamics in HIV-1 infection. Annu Rev Immunol 21:265-304,2003. |
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| Wed, April 13 | The Response of the Immune System to HIV | Beth Jamieson |
| Slide Presentation (Powerpoint) | ||
| Slide Presentation (PDF) | ||
| Glossary of terms | ||
| Hopkin M. Can superantibody drugs be tamed? Nature 440:855-856, 2006 | ||
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Huston DP. The biology of the immune system. JAMA 278(22):1804-1814, 1997. |
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| Fri, April 15 |
Clinical Manifestations of HIV Infection: Therapeutic Rationale and Treatment of HIV Infection |
Ronald Mitsuyasu |
| Slide Presentation Powerpoint PDF | ||
| Supplemental information on clinical manifestations and treatment regimens (not presented in class) Powerpoint PDF | ||
|
Reading |
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| Detels R, Muñoz A, McFarlane G, Kingsley LA, Margolick J, Giorgi J, Schrager LK, Phair JP. Effectiveness of potent antiretroviral therapy on time to AIDS and death in men with known HIV infection duration. JAMA 1998;280(17):1497-1503. | ||
| Sax PE, Baden LR. When to start antiretroviral therapy - ready when you are? NEJM 360:1897, 2009. | ||
| Kitahata MM, et al. Effect of early versus deferred antiretroviral therapy for HIV survival. NEJM 360:1815-26, 2009. | ||
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| Wed, April 20 | Pathologic and Neurologic Manifestations of HIV/AIDS | |
| Slide Presentation Powerpoint PDF |
Eric Miller 10-11 |
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| Slide Presentation Powerpoint PDF | Harry Vinters 11-noon | |
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Readings |
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Anthony IC, Bell JE. The neuropathology of HIV/AIDS. Intl Rev Psychiatr 20(1):15-24, 2008. |
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| Brew BJ, Letendre SL. Biomarkers of HIV related central nervous system disease. Intl Rev Psychiatr 20(1):73-88. | ||
| Power C, Gill MJ, Johnson RT. The neuropathogenesis of HIV infection: host-virus interaction and the impact of therapy. Can J Neurol Sci 29:19-32, 2002. | ||
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Hinkin CH, Castellon SA, van Gorp WG, Satz P. Neuropsychological features of HIV disease. In Practitioner's Guide to the Neuropsychiatry of HIV/AIDS, van Gorp WG, Buckingham SL (eds). The Guildford Press, New York, NY, 1998, Chapter 1, pp. 1-41. |
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Ellison D, Love S, Chimelli L, Harding BN, Lowe J, Vinters HV. Neuropathology: A Reference Text of CNS Pathology, 2nd ed. Mosby, London, England, 2004, pp. 300-318. |
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| (NOTE: If your computer cannot open the link for this, save to your hard disk and open the file through PDF) | ||
| Fri, April 22 | HIV/AIDS in the African-American Community | Nina Harawa |
| Slide Presentation Powerpoint PDF | ||
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Readings |
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| Bogart LM, Thorburn S. Are HIV/AIDS conspiracy beliefs a barrier to HIV prevention among African Americans? JAIDS 38(2):213-219, 2005. | ||
| Wohl AR, Johnson DF, Lu S, Jordan W, Beall G, Currier J, Simon PA. HIV risk behaviors among African American men in Los Angeles County who self-identify as heterosexual. JAIDS 31:354-360, 2002. | ||
| African Americans and HIV/AIDS. Kaiser Family Foundation Fact Sheet, February 2005. | ||
| Wilson P. Left Behind: Black America: A Neglected Priority in the Global AIDS Epidemic. IAS Newsletter, March 2009 | ||
| HIV/AIDS Amongst Black Americans. International AIDS Society Newsletter, March 2009 | ||
| Wed, April 27 | MIDTERM | |
| 2011 midterm key | ||
| Midterm results | ||
| Fri, April 29 | HIV/AIDS in the Gay Community | Lee Kozinski |
| Slide Presentation Powerpoint PDF | ||
|
Reading |
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Wolitski RJ, Valdiserri RO, Denning PH, Levine WC. Are we headed for a resurgence of the HIV epidemic among men who have sex with men? Am J Public Hlth 91:883-888, 2001. |
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Smith DK, et al. Interim Guidance: Preexposure Prophylaxis for the Prevention of HIV Infection in Men Who Have Sex with Men. MMWR 60(3):65-68, 2011. |
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| Wed, May 4 | HIV/AIDS in the Latino Community | Octavio J. Vallejo |
| HIV Infectious amongst Latinos Powerpoint PDF | ||
| HIV/AIDS among Latinos in California (PDF) | ||
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Reading |
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| Latino Congressional Briefing | ||
| HIV/AIDS among Mexican Migrants and Recent Immigrants in California and Mexico | ||
| Fri, May 6 | Vertical Transmission of HIV and Pediatric AIDS | Yvonne Bryson |
| Slide Presentation Powerpoint PDF | ||
|
Reading |
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| Beckerman KP. Long-term findings of HIVNET 012: the next step. Lancet 362:842-843, 2003. | ||
| Wed, May 11 | Bloodborne Transmission of HIV - class will last less than 2 hours, since Dr. Herron must go to airport | Ross Heron, American Red Cross |
| Slide Presentation Powerpoint PDF | ||
| Handout for class: HIV Transmission Through Transfusion — Missouri and Colorado, 2008. MMWR 59(41):1335-1339, 2010. | ||
| Fri, May 13 | HIV/AIDS and Drug Use in the U.S. (10:00-11:00) | Steven Shoptaw |
| Slide Presentation Powerpoint PDF | ||
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Reading |
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| Specter M. Higher risk. The New Yorker, pp 38-45; May 23, 2005. | ||
| HIV/AIDS and Drug Use in Asia (11:00-noon) | Roger Detels | |
| Slide Presentation Powerpoint PDF | ||
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Readings (Detels) |
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| Tran NT, Detels R, Nguyen TH, Hoang TL, Pham THN. Drug use, sexual behaviours and practices among male drug users in Hanoi, Vietnam. Int J Drug Policy 15(3):182-188, 2004. | ||
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Tran NT, Detels R, Long HT, Lan HP. Drug use among female sex workers in Hanoi, Vietnam. Addiction 100:619-625, 2005. |
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| Wed., May 18 | Behavioural Intervention Powerpoint PDF | Dallas Swendeman |
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Reading |
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Rotheram-Borus MJ, Swendeman D, Flannery D, Rice E, Adamson DM, Ingram B. Common factors in effective HIV prevention programs. AIDS Behav 13:399–408, 2009. |
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| Innovation in sexually transmitted disease and HIV prevention: Internet and mobile phone delivery vehicles for global diffusion. Curr Op Psychiatry 23:139–144, 2010. | ||
| The Past, Present, and Future of HIV Prevention: Integrating Behavioral, Biomedical, and Structural Intervention Strategies for the Next Generation of HIV Prevention. Annu Rev Clin Psychol 5:143–67, 2009. | ||
| Fri, May 20 | Surveillance Strategies/Testing | Roger Detels |
| Slide Presentation Powerpoint PDF | ||
|
Reading |
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| Sullivan SG, Wu Z, Detels R. Missed opportunities for testing in Asia. | ||
| Berkelman RL, Sullivan PS, Buehler JW. Public health surveillance. In: Detels R, McEwen J, Beaglehole R, Tanaka H, eds. Oxford Textbook of Public Health: The Methods of Public Health, vol 2, 5th ed. Oxford, England: Oxford University Press, 2009, pp. 699-715. | ||
| Revised Surveillance Case Definitions for HIV Infection Among Adults, Adolescents, and Children Aged <18 Months and for HIV Infection and AIDS Among Children Aged 18 Months to <13 Years --- United States, 2008. MMWR 57(RR10);1-8, 2008. | ||
| AIDS in Uganda - LA Times, May 2010 | ||
Bierly A. Community Involvement Raises HIV Testing Rates. http://www.nih.gov/researchmatters/may2011/05162011community.htm |
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| Wed, May 25 | Federal and State Policy Regarding HIV/AIDS | Arleen Leibowitz |
| Slide Presentation Powerpoint PDF | ||
| Reading | ||
| Zuniga JM. IAPAC recommendations to the Obama Administration for the US response to the global HIV pandemic. JIAPAC 1:13-20, 2009. | ||
| El-Sadr WM, Mayer KH, Hodder SL. AIDS in America - Forgotten but not gone. NEJM 362(11):967, 2010. | ||
| Fri, May 27 | Ethics of HIV/AIDS | Roger Detels |
| Slide Presentation Powerpoint PDF | ||
|
Reading |
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| The Declaration of Helsinki. October 2000. | ||
| Calman KC, Downie RS. Ethical principles and ethical issues in public health. In Oxford Textbook of Public Health: The Practice of Public Health, Detels R, McEwen J, Beaglehole R, Tanaka H (eds). Oxford University Press, Oxford England, 2002, pp. 387-399. | ||
| Wed., June 1 | The Multicenter AIDS Cohort Study (MACS) | Roger Detels |
| John Oishi | ||
| Slide Presentation Powerpoint PDF | ||
| Fri, June 3 | Public Health Intervention | Roger Detels |
| Slide Presentation Powerpoint PDF | ||
| HIV Vaccine Glossary, NIAID, 2002 | ||
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Readings |
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| UNAIDS, 2006 | ||
| Kresge KJ. And the winner is... HIV treatment and prevention. IAVI Report 11(1):1-5, 2007 | ||
| PEPFAR and the fight against HIV/AIDS. Lancet 369(9568):1141, 2007 | ||
| Mark Dybul: US Global AIDS coordinator in charge of PEPFAR. Lancet 369(9568):1161, 2007 | ||
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Ho DD. A shot in the arm for AIDS vaccine research. Public Library of Science 2(2):100-101, 2005. |
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| Coordinating Committee of the Global HIV/AIDS Vaccine Enterprise. The Global HIV/AIDS vaccine enterprise: scientific strategic plan. Public Library of Science 2(2):100-101, 2005. | ||
| Wu Z, Sun X, Sullivan, SG, Detels R. HIV testing in China. Science 312:475-476, 2006. | ||
| Treating TB, AIDS co-infection: http://www.hindu.com/seta/2009/05/21/stories/2009052150101200.htm | ||
| Reading: Initiation of ART | ||
| Wood R, Lawn SD. Should the CD4 threshold for starting ART be raised? Lancet 373:1314-16, 2009. | ||
| When to Start Consortium. Timing of initiation of ART in AIDS-free HIV-1-infected patients: a collaborative analysis of 18 HIV cohort studies. Lancet 373:1352-63, 2009. | ||
| Leibowitz A, et al. US Policy Perspective on Oral Preexposure Prophylaxis for HIV. AJPH 2011 | ||
| Final exam - Thursday, 9 June, 11:30 - 2:30 | ||
| Review session Tuesday, 7 June, 3-4 pm, room 61-269 | ||
| 2011 final key FINAL RESULTS | ||